Oncotype DX® Breast DCIS Score
AGE71

71 Year-Old Female Patient

with 1.2 cm Tumor

Patient Details

Post-Menopausal
1.2 cm
ER positive
No
1 mm
2
Present
Fair
Positive ≥ 6.5
Negative < 5.5
TREATMENT GIVEN: Patient declined radiation therapy, taking hormonal therapy

Clinical Experience

Prognosis for DCIS Patients

The clinical validation study1 included female patients with DCIS treated with local excision without irradiation, and required clear surgical margins ≥3 mm and a lesion size of ≤2.5 cm. Approximately a third of patients were treated with tamoxifen. The average 10 year rate for ipsilateral breast events for patients who had a DCIS Score of 52 was:

DCIS Score 52

Quantitative hormone receptor analysis

The Oncotype DX test uses RT-PCR to determine the RNA expression of the genes below. These results may differ from ER or PR results reported using other methods or reported by other laboratories.

ER Score≥12.5
PR Score5.9
PR Score by Oncotype DX

References

1. Solin et al. J Natl Cancer Inst. 2014.
2. Rakovitch et al. Breast Cancer Res Treat. 2015.
3. Rakovitch et al. ASCO. 2017.

Disclaimer: These case studies are brought to you for educational purposes only and should not be interpreted as an endorsement of Genomic Health or its services by the submitting physician, or any other product or therapy. The information is sometimes related to interpretive diagnostic opinions of the treating physicians, and is not intended to represent the “standard of care.” The case studies reflect real life cases of patients who have used Oncotype DX, however they are individual results and results do vary. The examples are not necessarily representative of all of those who will use our clinical tests. Genomic Health does not endorse any of the contributors featured on this site.

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AGE71
DCIS SCORE™52
ER Score≥12.5
PR Score5.9